Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain

Activin A regulates activation of mouse neutrophils by Smad3 signalling

Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease. However, whether activin A can exert an effect on the activities of neutrophils remains unclear. In this study, we found that the release of activin A was enhanced from neutrophils of mouse whe...

Anti-hyperalgesic effect of electroacupuncture in a model of post-incisional pain in rats.

Electroacupuncture has been proposed to be a low cost and practical method that allows effective pain management with minimal collateral effects. In this study we have examined the effect of electroacupuncture against the hyperalgesia developed in a model of post-incisional pain in rats. A 1-cm longitudinal incision was made through the skin and fascia of the plantar region of the animal hind p...

Transcutaneous electrical nerve stimulation for the relief of post-incisional surgical pain.

Incisional Injection of Magnesium Sulfate for Post-Cesarean Section Pain Management

Background: Effective pain relief is very important for parturient women because they are expected to recover expeditiously and to care for their newborns within a few hours following surgery. Recent studies have identified N-methyl-D aspartate (NMDA) receptors peripherally and their major role in nociceptive transmission. Magnesium has an antagonistic effect on NMDA receptors. Objectives: The ...

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF

Microvascular plasma protein leakage is an essential component of the inflammatory response and serves an important function in local host defense and tissue repair. Mediators such as histamine and bradykinin act directly on venules to increase the permeability of endothelial cell (EC) junctions. Neutrophil chemoattractants also induce leakage, a response that is dependent on neutrophil adhesio...